Two-Game Series at Pittsburgh Pirates
Series split 1-1
Giolito 
Anderson
Tuesday, June 22, 2021 at 6:05 pm CDT
PNC Park
Lucas Giolito, RHP vs.
Pirates / Tyler Anderson, LHP
L, 6-3, 43-30 (.589), L5 | LP: Garrett Crochet (2-4, 2.78) | Game 73
Game highlights from mlb.com
Cease 
De Jong
Wednesday, June 23, 2021 at 11:35 am CDT
PNC Park
Dylan Cease, RHP vs.
Pirates / Chase De Jong, RHP
W, 4-3, 44-30 (.595), W1 | WP: Dylan Cease (6-3, 3.81) | S: Liam Hendriks (19) | Game 74
Game highlights from mlb.com
Three-Game Series vs. Seattle Mariners
Mariners win series 2-1
Rodón 
Kikuchi
Friday, June 25, 2021 at 7:10 pm CDT
Guaranteed Rate Field
Carlos Rodón, LHP vs.
Mariners / Yusei Kikuchi, LHP
L, 9-3, 44-31 (.587), L1 | LP: Carlos Rodón (6-3, 2.06) | Game 75
Game highlights from mlb.com
Lynn 
Gilbert
Saturday, June 26, 2021 at 1:10 pm CDT
Guaranteed Rate Field – Suspended
Lance Lynn, RHP vs.
Mariners / Logan Gilbert, RHP
L, 3-2, 44-32 (.579), L2 | LP: Liam Hendriks (3-2, 2.23) | Game 76
Game suspended in the bottom of the 3rd and completed (9 innings total) on Sunday (June 27), prior to the regularly scheduled game. Left-hander Héctor Santiago became the first player in Major League Baseball to be ejected for using an illegal grip-enhancing agent since the league began mandatory umpire checks on Monday, June 21. Watch game highlights from mlb.com:
Burr 
Dugger
Sunday, June 27, 2021 at 4:15 pm CDT
Guaranteed Rate Field – 7-inning game
Ryan Burr, RHP vs.
Mariners / Robert Dugger, RHP
W, 7-5, 45-32 (.584), W1 | WP: Aaron Bummer (1-4, 3.26) | S: Liam Hendriks (20) | Game 77
Game highlights from mlb.com